1 Introduction Tissue-integrated devices are an important class of biomedical instruments that aid in optimizing performance of the human body.[1-8] These devices include wearable and implantable biochemical and biophysical sensors,[9-16] drug delivery platforms,[17-19] and organ function optimizing devices, such as pacemakers[20, 21] and implantable cardiac defibrillators.[22-24] Tissue-integrated sensors enable close monitoring of various metabolic, electrolytic, proteomic, electrical,...