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Featured ArticleResearch Articles, Cellular/Molecular Marta Maiolino, Nathanael O'Neill, Vincenzo Lariccia, Salvatore Amoroso, Sergiy Sylantyev, Plamena R. Angelova and Andrey Y. Abramov Journal of Neuroscience 31 July 2019, 39 (31) 6038-6048; DOI: https://doi.org/10.1523/JNEUROSCI.0314-19.2019 Abstract Glutamate is one of the most important neurotransmitters in the process of signal transduction in the CNS.
Introduction Neuronal metabotropic glutamate receptors Group I (mGluRIs) are classically viewed as the modulators (predominantly augmentative) of NMDA receptors (NMDARs); G-protein signaling cascades are the transfer mechanism of this modulation (Rossi et al., 1996; Kunishima et al., 2000; Pin and Acher, 2002). This signaling mechanism can be interrupted by blocking various stages of the G-protein cascade.
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