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Neng Bao

As seen in: Nature
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Articles by Neng Bao

RNF130 ameliorates renal injury and inflammation by inhibiting macrophage pyroptosis through ubiquitination degradation of PDCD4 in male mice

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By Xue-Xue Zhu, Le Yang, Yuan-Yuan Wen, Min Wei, Gui-Wen Xu, Ming-Heng Liu, You-Yi Zhuang, Hao-Dong Li, Mehrdad Ghashghaeinia, Florian Lang, Si-ping Xiong, Xing Li, Qing-Bo Lu, Hai-jian Sun, Ao-Yuan Zhang, Sheng-Qi Gao, Neng Bao, Guan-Li Zheng
| Nature Verified
Abstract Macrophage pyroptosis has been identified as a contributor to acute kidney injury (AKI), but the underlying mechanisms involved remain unclear. Herein, we identify that ring finger protein 130 (RNF130) RNF130 is significantly downregulated in both mice and patients with AKI. Myeloid cell-specific loss of RNF130 aggravates renal pathological damage and facilitates macrophage pyroptosis in AKI mouse models.
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