Introduction Reperfusion therapies, including intravenous thrombolysis (IVT), endovascular treatment (EVT), and IVT plus EVT, are the standard of care and lead to improved clinical outcomes of acute ischemic stroke due to large-vessel occlusion (AIS-LVO). Both IVT and EVT are highly time-dependent and involve selecting patients based on the extent of ischemic damage (Powers et al., 2019). Large infarction extent is in relation to poor functional outcome and the risk of symptomatic hemorrhage.