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Nicholas D.E

As seen in: Frontiers
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Articles by Nicholas D.E

The actions of methotrexate on endothelial cells are dependent on the shear stress-induced regulation of one carbon metabolism

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By Pier Luigi Meroni, Jenn-Haung Lai, Nicholas D.E
| Frontiers
1 Introduction It has long been appreciated that patients with chronic systemic inflammatory diseases, including rheumatoid arthritis (RA), have an increased risk of cardiovascular disease (CVD) (1). Patients with RA display impaired endothelial function (2, 3), which is known to promote atherogenesis and is likely accelerated by the pro-inflammatory environment present in these patients (4).
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Host-microbe co-metabolism dictates cancer drug efficacy in C. elegans

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By Nicholas D.E
| gla.ac.uk
Scott, T. A. et al. (2017) Host-microbe co-metabolism dictates cancer drug efficacy in C. elegans. Cell, 169(3), 442-456.e18. (doi: 10.1016/j.cell.2017.03.040) (PMID:28431245) (PMCID:PMC5406385) Full text not currently available from Enlighten. Abstract Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy.
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