Microbiota is an important factor in determining the health and disease factors. Theory of microecology stated that ecological balance between neural, endocrine, microbial, metabolic, and immune systems is eminent of life sustainability (Du et al., 2019). Oral cavity and gut are two vital gastrointestinal tract structures that comprise a microbial consortium which is mainly responsible for energy intake and metabolic processing essential for human health (Maki et al., 2021).