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Articles by Niharika Bala
Targeted lipidomics between hPheo1 and SDHB KD cells reveal changes in bioactive lipids and PKC with polyamine pathway inhibition
1 INTRODUCTION Pheochromocytomas (PCCs) and paragangliomas (PGLs) (PCPG's) are rare neuroendocrine tumors (Juhlin, 2021). However, PCPG patients with mutations in the succinate dehydrogenase subunit B (SDHB) gene have a greater incidence of metastatic disease. Moreover, metastatic PCPG's usually present as advanced tumors with limited treatment options.
Activity and function of the endothelial sodium channel is regulated by the effector domain of MARCKS like protein 1 in mouse aortic endothelial cells
Abstract The endothelial sodium channel (EnNaC) plays an important role in regulating vessel stiffness. Here, we investigated the regulation of EnNaC in mouse aortic endothelial cells (mAoEC) by the actin cytoskeleton and lipid raft association protein myristoylated alanine-rich C-kinase substrate like protein 1 (MLP1).
Biomedicines | Free Full-Text | Enrichment of Bioactive Lipids in Urinary Extracellular Vesicles and Evidence of Apoptosis in Kidneys of Hypertensive Diabetic Cathepsin B Knockout Mice after Streptozotocin Treatment
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Augmentation of Cathepsin Isoforms in Diabetic db/db Mouse Kidneys Is Associated with an Increase in Renal MARCKS Expression and Proteolysis
Abstract : The expression of the myristoylated alanine-rich C-kinase substrate (MARCKS) family of proteins in the kidneys plays an important role in the regulation of the renal epithelial sodium channel (ENaC) and hence overall blood pressure regulation. The function of MARCKS is regulated by post-translational modifications including myristoylation, phosphorylation, and proteolysis.
Biomedicines | Free Full-Text | Decreased MARCKS Protein Expression in Kidney Cortex Membrane Fractions of Cathepsin B Knockout Mice Is Associated with Reduced Lysophosphatidylcholine and Protein Kinase C Activity
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Tamim Kawakibi 1,†, Niharika Bala 1,†, Lauren P. Liu 1, Louis A. Searcy 2, Nancy D. Denslow 2 and Abdel A.
Human Alpha-1 Antitrypsin Attenuates ENaC and MARCKS and Lowers Blood Pressure in Hypertensive Diabetic db/db Mice
Abstract : Hypertension may develop before or after the onset of diabetes and it is known to increase the risk of developing diabetic nephropathy. Alpha-1 antitrypsin (AAT) is a multi-functional protein with beneficial effects in various diseases but its role in reducing blood pressure in the diabetic kidney has not been thoroughly studied.
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