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Nils Halberg

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Articles by Nils Halberg

PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels - Nature Metabolism

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By Qingzhang Zhu, Jan-Bernd Funcke, Leon G. Straub, Shangang Zhao, Zhuzhen Z. Zhang, Christy M. Gliniak, Nils Halberg, Ruth Gordillo
| Nature Verified
Abstract PAQR4 is an orphan receptor in the PAQR family with an unknown function in metabolism. Here, we identify a critical role of PAQR4 in maintaining adipose tissue function and whole-body metabolic health. We demonstrate that expression of Paqr4 specifically in adipocytes, in an inducible and reversible fashion, leads to partial lipodystrophy, hyperglycaemia and hyperinsulinaemia, which is ameliorated by wild-type adipose tissue transplants or leptin treatment.
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Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases - Nature Cancer

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By Paula I. Gonzalez-Ericsson, Jeffrey McDonald, Gonçalo Vale, Nils Halberg, Carlos L. Arteaga, Ariella B. Hanker, Ralph J. DeBerardinis
| Nature Verified
Abstract Disseminated tumor cells with metabolic flexibility to utilize available nutrients in distal organs persist, but the precise mechanisms that facilitate metabolic adaptations remain unclear. Here we show fragmented mitochondrial puncta in latent brain metastatic (Lat) cells enable fatty acid oxidation (FAO) to sustain cellular bioenergetics and maintain redox homeostasis.
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