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By John Longsworth, Nina Schillings, and Ma Sha Eppendorf bioprocess controllers, such as the BioFlo® 320 Bioreactor Control System, use a proportional– integral–derivative (PID) control mechanism for a variety of processes, including dissolved oxygen (DO) control. The PID control loop mechanism for DO control is essential for optimal bioreactor cell culture. Although the D value is not user adjustable in Eppendorf controllers, the P and I values can be changed.
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