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Background T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive malignancy caused by clonal proliferation of transformed thymic T-cell progenitor cells. It accounts for about 15% of pediatric ALL cases and 25% of adult ALL cases. Although there are distinct features in the demographics, clinical presentation, biology, and genetic landscape of T-ALL, it is still treated with chemotherapy, like that used in B-cell acute lymphoblastic leukemia (B-ALL).
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