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Abstract Sex differences are recognized in Parkinson’s disease (PD), but their epigenetic basis remains incompletely understood. We performed a two-stage epigenome-wide meta-analysis of DNA methylation to characterize sex-differential methylation profiles in PD. The discovery stage included blood samples from 1143 patients with PD and 1013 matched healthy controls from two independent datasets.
Abstract Whether blood biomarkers can predict the development of motor complications in early-stage Parkinson’s disease (PD) remains unclear. In this prospective longitudinal cohort study, 173 patients with early-stage PD were followed for up to seven years.
Abstract Parkinson’s disease (PD) is a heterogeneous movement disorder with different motor subtypes including tremor dominant (TD), indeterminate and postural instability, and gait disturbance (PIGD) motor subtypes. Plasma glial fibrillary acidic protein (GFAP) was elevated in PD patients and may be regarded as a biomarker for motor and cognitive progression.
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