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Articles by Nir Giladi
Beyond RBD: covert REM sleep abnormalities in Parkinson’s disease - npj Parkinson's Disease
Abstract REM sleep behavior disorder (RBD), involving REM sleep without atonia (RSWA), is a prodromal marker of Parkinson’s disease (PD). We investigated whether RBD may represent the “tip of the iceberg” of pathology driving wider REM sleep disruptions. In this study, 25 early-stage, drug-naïve PD patients and 23 age-matched healthy controls underwent overnight polysomnography with high-density EEG (256 channels) to assess how sleep patterns relate to generalized motor learning (GML).
Paroxysmal Slow-Wave Events Are Uncommon in Parkinson’s Disease
Abstract : Background: Parkinson’s disease (PD) is currently considered to be a multisystem neurodegenerative disease that involves cognitive alterations. EEG slowing has been associated with cognitive decline in various neurological diseases, such as PD, Alzheimer’s disease (AD), and epilepsy, indicating cortical involvement. A novel method revealed that this EEG slowing is composed of paroxysmal slow-wave events (PSWE) in AD and epilepsy, but in PD it has not been tested yet.
Neural Variability in the Prefrontal Cortex as a Reflection of Neural Flexibility and Stability in Patients With Parkinson Disease
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Glucocerebrosidase Activity is not Associated with Parkinson's Disease Risk or Severity
ABSTRACT Background Mutations in the GBA gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are risk factors for Parkinson's disease (PD). Objective To explore the association between GCase activity, PD phenotype, and probability for prodromal PD among carriers of mutations in the GBA and LRRK2 genes. Methods Participants were genotyped for the G2019S-LRRK2 and nine GBA mutations common in Ashkenazi Jews.
Executive Control Deficits as a Prodrome to Falls in Healthy Older Adults: A Prospective Study Linking Thinking, Walking, and Falling
J Gerontol A Biol Sci Med Sci. 2010 Oct; 65A(10): 1086–1092. Talia Herman,1 Anat Mirelman,1,2 Nir Giladi,1,3 Avraham Schweiger,4,5 and Jeffrey M.
Safety and efficacy of venglustat in GBA1-associated Parkinson's disease: an international, multicentre, double-blind, randomised, placebo-controlled, phase 2 trial
Background Variants in the GBA1 gene, which encodes lysosomal acid glucocerebrosidase, are among the most common genetic risk factors for Parkinson's disease and are associated with faster disease progression. The mechanisms involved are unresolved but might include accumulation of glucosylceramide. Venglustat is a brain-penetrant glucosylceramide synthase inhibitor that, in previous studies, reduced amounts of the glycosphingolipid.
Gait Measures as Predictors of Poststroke Cognitive Function
Background and Purpose—Patients with stroke are at risk for developing cognitive impairment. We tested whether the assessment of balance and gait can enhance the prediction of long-term cognitive outcome in stroke survivors.
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