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What is the current knowledge on the topic? ○ Antibody Drug Conjugate (ADC) linkers are typically designed to be stable in the systemic circulation. However, the long systemic half-life of the conjugated payload can result in sustained exposure to low levels of the unconjugated payload over time. The unconjugated payload and/or its metabolites may pose potential risks for drug–drug interactions (DDI).
Abstract Tissue clearing and Light sheet fluorescence microscopy (LSFM) provide spatial information at a subcellular resolution in intact organs and tumors which is a significant advance over tools that limit imaging to a few representative tissue sections. The spatial distribution of drugs, targets, and biomarkers can help inform relationships between exposure at the site of action, efficacy, and safety during drug discovery.
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