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Articles by Nong Lu
A Photoisomerizable Zinc (II) Complex Inhibits Microtubule Polymerization for Photoactive Therapy
Graphical Abstract This work highlights a photoisomerizable zinc(II) complex (Zn1), which has a promising application prospect in photoactive therapy through photoisomerization. Zn1 can release its trans ligand after light irradiation, undergo photoisomerization to produce toxic cis product and generate 1O2 in the meantime. The series of changes lead to photo-triggered toxicity against cancer cells and cause microtubule breakdown.
Ferroptosis promotes sonodynamic therapy: a platinum(II)–indocyanine sonosensitizer
Ferroptosis promotes sonodynamic therapy: a platinum(ii)–indocyanine sonosensitizer† Yidan Lai,‡a Nong Lu,‡a Ai Ouyang,‡a Qianling Zhang a and Pingyu Zhang *a Abstract Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its deep penetration depth, showing great preclinical and clinical potential. Herein, a platinum(II)–cyanine complex has been designed to investigate its potential as a SDT anticancer agent.
Near-infrared phosphorescent terpyridine osmium(Ⅱ) complexes photosensitizers for photodynamic and photooxidation therapy
Near-infrared phosphorescent terpyridine osmium(Ⅱ) complexes photosensitizers for photodynamic and photooxidation therapy Ge Chen, Jiayi Zhu, Ai Ouyang, Nong Lu, Yi Wang, Qianling Zhang and Pingyu Zhang Abstract Osmium(II) complexes usually exhibit an excellent NIR (near-infrared) emission, which conforms to the optical window in a biological system.
Microenvironment-sensitive iridium(III) complexes for diseases theranostics
Microenvironment-sensitive iridium(III) complexes for diseases theranostics Microenvironmental parameters, including hypoxia, pH, polarity, viscosity and temperature, play pivotal roles in controlling the biological physical or chemical behaviors of local molecules. Abnormal changes in these parameters would cause cellular malfunction or become a hallmark of the occurrence of severe diseases.
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