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1 Introduction Streptococcus mutans, an important etiological agent of dental caries, carries six LPXTG-anchored surface proteins, namely (i) Antigen I/II (AgI/II), (ii) Glucan-binding protein C (GbpC), (iii) Fructanase (FruA), (iv) Dextranase (DexA), Cell wall-associated proteins (v) WapA, and (vi) WapE (Avilés-Reyes et al. 2017; Katsumata et al. 2022). In addition, another unique collagen-binding protein, Cnm, is more commonly found in a selective group of S.
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