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Abstract Cancer-associated fibroblasts (CAFs) are key stromal cells in the tumor microenvironment (TME) and play critical roles in tumor progression and radioresistance. Radiotherapy kills malignant cells but also triggers stress in CAFs, which alters their phenotype and affects nearby tumor cells. However, how irradiated CAFs influence the survival and radioresistance of nasopharyngeal carcinoma (NPC) cells remains unclear.
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