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Articles by Okechukwu Paul-Chima
Climate-sensitive fall risk in ageing populations: a public health perspective
Abstract Falls among older adults are a leading cause of injury, disability and mortality worldwide, with an estimated 684,000 fall deaths each year and the greatest fatal burden among adults older than 60 years. Current multifactorial fall prevention stratifies risk at the level of the individual and the clinical encounter, and treats environmental hazards largely as static features of the home.
Programmable RNA therapeutics: converging vaccination and on-demand disease treatment via self-adaptive RNA platforms
Abstract RNA technology, most prominently messenger RNA (mRNA), has transformed vaccine development by enabling rapid, sequence-specific antigen design, scalable manufacturing, and transient protein expression. Its long-term significance, however, extends beyond prophylactic vaccination. This Perspective argues that mRNA should be conceptualised as a programmable therapeutic platform capable of integrating vaccination, immune modulation, and on-demand disease treatment.
The vaccination paradox: how East Africa’s success in Ebola vaccine preparedness may be creating new public expectations for future outbreaks
Abstract This perspective synthesizes published evidence on Ebola vaccination and outbreak preparedness in Africa. Successful vaccination against Zaire ebolavirus has strengthened vaccine-based outbreak control but may also create a preparedness risk when public expectations exceed species-specific vaccine availability.
Circular RNA therapeutics: a new class of long-acting RNA medicines for oncology, immunology, and rare diseases
Abstract Circular RNAs (circRNAs) have progressed from being viewed as splicing by-products to emerging therapeutic constructs with a distinct pharmacology.
Harnessing technology for infectious disease response in... : Medicine
Infectious diseases outbreaks in conflict areas are intersections of humanitarian crises and public health emergencies which are complex and require creative solutions.[1] Such conflicts worsen existing vulnerabilities in healthcare infrastructure, interfere with surveillance and response activities, and make people more susceptible to the spread of disease.[2] Solving the problems of infectious diseases in such environments demands a comprehensive interdisciplinary response linking...
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