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Oleksandr Buzko

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Articles by Oleksandr Buzko

A recombinant ACE2 Triple Decoy that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants

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By Shiho Tanaka, Gard Nelson, Oleksandr Buzko, Anders Olson
| BioRxiv
New Results Shiho Tanaka, Gard Nelson, Anders Olson, Oleksandr Buzko, Wendy Higashide, Annie Shin, Marcos Gonzales, Justin Taft, View ORCID ProfileRoosheel Sandeep Patel, Sofija Buta, Marta Martin-Fernandez, Dusan Sandeep Bogunovic, Patricia R Spilman, Kayvan Niazi, Shahrooz Rabizadeh, View ORCID ProfilePatrick Soon-Shiong doi: https://doi.org/10.1101/2021.03.09.434641 Abstract The highly-transmissible SARS-CoV-2 variants now replacing the first wave strain pose an increased threat to human...
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Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an esca…

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By Gard Nelson, Oleksandr Buzko, Patricia Spilman, Kayvan R. Niazi
| BioRxiv
New Results Gard Nelson, Oleksandr Buzko, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, View ORCID ProfilePatrick Soon-Shiong doi: https://doi.org/10.1101/2021.01.13.426558 Abstract Rapidly spreading SARS-CoV-2 variants present not only an increased threat to human health due to the confirmed greater transmissibility of several of these new strains but, due to conformational changes induced by the mutations, may render first-wave SARS-CoV-2 convalescent sera, vaccine-induced antibodies,...
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Millisecond-scale molecular dynamics simulation of spike RBD structure reveals evolutionary adaption of SARS-CoV-2 to stably bind ACE2

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By Aaron Bassett, Patricia Spilman, Gard Nelson, Oleksandr Buzko
| BioRxiv
New Results Gard Nelson, Oleksandr Buzko, Aaron Bassett, Patricia Spilman, Kayvan Niazi, Shahrooz Rabizadeh, View ORCID ProfilePatrick Soon-Shiong doi: https://doi.org/10.1101/2020.12.11.422055 Abstract The Receptor Binding Domain (RBD) of the SARS-CoV-2 surface spike (S) protein interacts with host angiotensin converting enzyme 2 (ACE2) to gain entry to host cells and initiate infection1–3.
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