Background: Patients (pts) who develop biochemically recurrent prostate cancer (BRPC) after prostatectomy can be offered salvage radiation therapy (RT) to prostate bed and pelvis. The success of that strategy is contingent on the absence of metastases (mets). Standard imaging techniques including CT scan (CT) and bone scan (BS) have limited ability in localizing BRPC and better imaging is needed to guide therapy and prevent unnecessary salvage RT in pts with mets.