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P. Jeremy Wang

As seen in: Nature
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Articles by P. Jeremy Wang

Recruitment of TEX15 by HUSH2 drives repression of multicopy gene families in fertility regulation

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By Fang Yang, Sora Yoon, Ankit Jaiswal, Zhenlong Kang, N. Adrian Leu, Kevin Monahan Verified, P. Jeremy Wang
| Nature Verified
Abstract Chromatin-associated proteins are key regulators of fertility. While the testis-specific protein TEX15 and a HUSH2 component TASOR2 have established roles in early germ cells and somatic cells respectively, this study identifies their cooperative role during spermiogenesis. Postnatal loss of either TEX15 or TASOR2 in mice causes teratozoospermia without retrotransposon de-repression. Mechanistically, TEX15 complexes with TASOR2 but not its paralogue TASOR in the testis.
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The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

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By Manickam Gurusaran, Yasuhiro Fujiwara, P. Jeremy Wang, Jayakrishnan Nandakumar
| Nature Verified
Abstract Breast cancer susceptibility gene II (BRCA2) is central in homologous recombination (HR). In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here, we identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-helical N-terminus of MEILB2 and preventing MEILB2 self-association. BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex.
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