Tuberculosis treatment requires a combination of agents, many of which have side effects including anaphylaxis. Anaphylactic reactions to medications usually occur within minutes to a few hours of administration. We report on an unusual case of delayed anaphylactic shock to rifampin occurring many days after initiation of therapy. To read this article in full you will need to make a payment ACAAI Member Login ACAAI Member, full access to the journal is a member benefit.