Large-eddy simulations (LES) coupled to a model that simulates methane emissions from oil and gas production facilities are used to generate realistic distributions of meteorological variables and methane concentrations. These are sampled to obtain simulated observations used to develop and evaluate source term estimation (STE) methods. A widely used EPA STE method (OTM33A) is found to provide emission estimates with little bias when averaged over six time periods and seven well pads.