Pan Du
United States
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Articles by Pan Du
Renoprotective effects of tubular glucagon receptor activation mediated by V-ATPase
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Recent clinical trials have shown that dual GLP-1R/GCGR agonists, including mazdutide and cotadutide, provide kidney benefits in patients with type 2 diabetes and CKD, suggesting a potential contribution of GCGR activation to these renal effects.
High-throughput generation of patient-derived cancer stem cells for precision medicine using a microwell-chip platform
Abstract Substantial evidence indicates that cancer stem cells (CSCs) drive breast cancer (BRC) initiation, progression, therapy resistance, recurrence and metastasis. Evaluating drug efficacy against patient-derived CSCs can advance precision oncology. However, high-throughput isolation of functional CSCs from small clinical samples remains challenging. Tumoursphere formation, arising from the clonal expansion of a single cancer cell, is a standard in vitro method for CSC assay and enrichment.
DNA Repair gene alterations and efficacy from gemcitabine and nab-paclitaxel with/without durvalumab and tremelimumab in metastatic pancreatic ductal adenocarcinoma | Nature Communications
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Abstract The CCTG PA.7 study was a randomized phase II trial comparing chemotherapy with and without dual immune checkpoint inhibition in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC).
By Daniel Renouf, James Topham, Jonathan M Loree, David Schaeffer, Jennifer J. Knox, Petr Kavan, Derek J Jonker, Stephen R Welch, Félix Couture, Mustapha Tehfé, Yoo-Joung Ko, Patricia Tang, Ravi Ramjeesingh, Brandon Meyers, Christina Kim, Pan Du, Sharlene Gill, Dongsheng Tu, Chris O’Callaghan, Frederic Lemay, Mohammed Harb, Nathalie Aucoin, Shidong Jia, Joanna M. Karasinska
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Nature
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AI-powered automated model construction for patient-specific CFD simulations of aortic flows
Abstract Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and time-consuming, limiting their clinical applications. This study introduces a deep-learning framework that automates the creation of simulation-ready vascular models from medical images.
Ultra-sensitive detection of mutant KRAS in circulating tumor DNA predicts survival in resectable pancreatic adenocarcinoma
Abstract Introduction: Over 90% of pancreatic adenocarcinoma (PDAC) has a KRAS mutation, 98% of which are single-base missense variants occurring at codon 12 (G12), codon 13 (G13), or codon 61 (Q61), with numerous studies demonstrating their clinical utility. Mutant KRAS has been detected in circulating tumor DNA (ctDNA) at all stages of PDAC using analysis methods such as next-generation sequencing (NGS).
Comprehensive Risk Assessment of Smart Energy Information Security: An Enhanced MCDM-Based Approach
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Pre‐Established Ion Transport Pathways Through Electrolyte Initiator for High‐Efficiency Polymer Interface Enabling Ultra‐Stable Aqueous Zinc‐Metal Anodes
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202418741-sup-0001-SuppMat.docx18.1 MB Supporting Information References 1a) , , , Adv. Energy Mater. 2020, 10, 2001445; b) , , , Adv. Energy Mater. 2017, 7, 1700663; c) , , , , , , Energy Environ. Sci. 2020, 13, 3917. 2a) , , , Chem. Sci. 2022, 13, 8243; b) , , , , , , , Nano Energy 2020, 70, 104523; c) , , Nat. Rev. Mater.
Modified metal-organic frameworks for sonophotocatalytic elimination of wastewater pollutants
CONFLICT OF INTEREST STATEMENT None of the authors have a conflict of interest to disclose. REFERENCES 1, , , , , , , J. Hazard. Mater. 2021, 412, 125245. 2, , , , , , , , Nanomaterials 2022, 12, 1679. 3, , , , , Energy Environ. Sci. 2014, 7, 2831. 4, , , , , Inorg. Chem. Front. 2020, 7, 300. 5, Chemosphere 2009, 75, 417. 6, , , , , Environ. Int. 2018, 115, 205. 7, , , , , , , J. Water Process Eng. 2022, 46, 102548. 8, , , , , , J. Ind. Eng. Chem. 2019, 77, 280. 9, , , , , , Sci. Total Environ. 2019, 663, 97.
Reconstructing Solvation Structure by Steric Hindrance‐Coordination Push‐Pull of Dipolymer‐H2O‐Zn2+ toward Long‐life Aqueous Zinc‐Metal Batteries
Conflict of interests The authors declare no competing interests. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Reconstructing Solvation Structure by Steric Hindrance‐Coordination Push‐Pull of Dipolymer‐H2O‐Zn2+ toward Long‐life Aqueous Zinc‐Metal Batteries
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Polydopamine in‐situ polymerized on graphene oxide for nitrile butadiene rubber with high strength, elasticity and aging resistance
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description pc27932-sup-0001-Tables.docxWord 2007 document , 30.2 KB Table S1. Formula of NBR composites. Table S2. The detailed definition of parameters of Flory-Rehner equation. Table S3. The details data of mechanical properties of NBR composites. Table S4. Modulus and N* at linear viscoelastic region of NBR composites. Table S5. Low-field NMR parameters of NBR composites.
Study on the rheological behavior of aqueous solutions of polyacryloylglycinamide
Study on the rheological behavior of aqueous solutions of polyacryloylglycinamide Poly(N-acryloylglycinamide) (PNAGA) exhibits an upper critical solution temperature (UCST) behaviour in aqueous solutions, and unlike typical polymers, dissolution is more sensitive to temperature and solutions may exhibit an extraordinary rheological behavior.
Facile preparation of physically crosslinked hydrogel based on the glassy state with high strength
Facile preparation of physically crosslinked hydrogel based on the glassy state with high strength Hydrogels are promising materials, but because of their weak mechanical performance, further applications are limited. To enhance the strength of hydrogels, physical cross-linking was introduced by the use of hydrophobic unit diacetone acrylamide (DAAM) to form cross-linking points. The homopolymer of DAAM exhibited a high glass transition temperature above 80 °C, which was confirmed by DSC.
Theoretical study of reductive CO2 functionalization with amines and phenylsilanes: What kind of solvents can be used as catalysts?
Theoretical study of reductive CO2 functionalization with amines and phenylsilanes: What kind of solvents can be used as catalysts? Pan Du, Xinyue Liu, Xinyi Dong, Nianyang Li, Rui Liu, Li Li and Jiyang Zhao Abstract In this study, the mechanisms of CO2 formylation and methylation with N-methylaniline and PhSiH3 were investigated using density functional theory (DFT) calculations, and the chemical selectivity of the reaction towards formamide or methylamine products was analyzed.
The Nocardia Rubra Cell Wall Skeleton Regulates Macrophages and Promotes Wound Healing
Abstract : The Nocardia rubra cell wall skeleton (Nr-CWS) is an immunomodulator used clinically for its ability to modulate the body’s immune function. Macrophages are an important hub of the immune response during wound healing. In this study, we hypothesized that a Nr-CWS could modulate macrophage physiological activities, polarize macrophages toward M2, and promote wound healing.
Phase-junction Engineering Boosts the CoSe2 for Efficient Sodium/Potassium Storage
Phase-junction Engineering Boosts the CoSe2 for Efficient Sodium/Potassium Storage Sodium ion batteries (SIBs) and potassium ion batteries (PIBs) are the most promising alternative candidates for the lithium ion batteries (LIBS), owing to their natural abundance and low-cost. Herein, the unique cubic / orthorhombic-CoSe2 phase-junction (c/o-CoSe2) anchored on SiC nanowires (NWs) (denoted as c/o-CoSe2@SiC). The electron coupling effect of phase-junction interface promotes the diffusion of Na+/K+.
Taming the challenges of activity and selectivity in the electrochemical nitrogen reduction reaction using graphdiyne-supported double-atom catalysts
Taming the challenges of activity and selectivity in the electrochemical nitrogen reduction reaction using graphdiyne-supported double-atom catalysts Developing highly efficient electrocatalysts for the electrochemical nitrogen reduction reaction (eNRR) is becoming increasingly important but remains a great challenge due to the lack of strategies to solve the problem of activity and selectivity.
Single-atom-sized Ni‒N4 site anchored in three-dimensional hierarchical carbon nanostructures for oxygen reduction reaction
Single-atom-sized Ni‒N4 site anchored in three-dimensional hierarchical carbon nanostructures for oxygen reduction reaction The four-electron (4e‒) oxygen reduction reaction (ORR) is a basic reaction in fuel cells and metal-air batteries, but its wide use needs the development of efficient and inexpensive catalysts.
Design and Test of Tractor-Attached Laser-Controlled Rotary Scraper Land Leveler for Paddy Fields
Downloaded 37 times Technical Papers Abstract To realize high-efficiency and precision paddy field leveling, a tractor-attached laser-controlled rotary scraper land leveler for paddy fields was designed. An elevation model for the laser leveler’s scraper was established, and the elevation adjustment error was determined.
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