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Pan HL

As seen in: JNeurosci
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Articles by Pan HL

Presynaptic Enhancement of Transmission from Nociceptors Expressing Nav1.8 onto Lamina-I Spinothalamic Tract Neurons by Spared Nerve Injury in Mice

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By Chen SR, Zhou HY, Byun HS, Pan HL
| eneuro.org
brain slices chronic pain optogenetics spinal cord synaptic plasticity Significance Statement Altered synaptic function in the dorsal horn (DH) has been suggested as a possible cellular substrate for neuropathic pain. However, the type of synapse involved remains unclear. This study uses optogenetics to activate Nav1.8-expressing nociceptors and retrograde fluorescence tracing for whole-cell recordings from spinothalamic tract neurons (STTNs).
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NMDA Receptors at Primary Afferent-Excitatory Neuron Synapses Differentially Sustain Chemotherapy- and Nerve Trauma-Induced Chronic Pain

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By Chen SR, Zhou HY, Byun HS, Pan HL
| JNeurosci Verified
α2δ-1 dorsal root ganglion spinal cord K-Cl cotransporter-2 (KCC2) synaptic plasticity synaptic transmission Introduction Chronic neuropathic pain is often caused by peripheral nerve injury and certain cancer therapeutics. Both traumatic nerve injury and chemotherapy-induced neuropathy augment glutamate NMDAR activity in the spinal cord dorsal horn, which serves to amplify nociceptive input from primary sensory neurons (Woolf and Salter, 2000; H. Y. Zhou et al., 2011; Deng et al., 2019a).
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The α2δ-1-NMDA receptor complex and its potential as a therapeutic target for ischemic stroke

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By Chen SR, Pan HL
| ncbi.nlm.nih.gov
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