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Articles by Panagiotis Sakellariou
Further Insights Into the Metabolism of LGD‐4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites
1 Introduction LGD-4033 (also known as Ligandrol) is a non-steroidal Selective Androgen Receptor Modulator (SARM) that is frequently detected during sports drug testing [1], despite its inclusion in the prohibited list [2] of the World Anti-Doping Agency (WADA), due to its promising anabolic effects [3, 4]. It is extensively metabolized in the human body and the general structures of its long-term metabolites (M1–M6, Figure 1) have been described in the literature [6-10].
Further Insights Into the Metabolism of LGD-4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake
ABSTRACT Using a targeted metabolic investigation approach, a new, previously undescribed metabolite, which is a pyrrole derivative of LGD-4033, has been detected and coded as M8. This metabolite can be detected in postadministration human urine samples up to 6?days after administration. It has also been detected in post-administration samples, mimicking supplement contamination, after repeated 10??g doses detectable for ≥?120?h after administration.
Simplified Analysis of Native Steroid Esters in Dried Blood Spots by LC-MS3
1 Introduction The detection of anabolic androgenic steroids (AAS) in sports drug testing remains an important and critical component of anti-doping efforts worldwide. Traditionally, urine has served as the primary biological matrix for the detection of steroid abuse; however, alternative matrices such as dried blood spots (DBS) are gaining traction due to their minimally invasive sampling, ease of transport and potential for improved analyte stability [1].
Simultaneous quantitation and identification of intact Nandrolone phase II oxo‐metabolites based on derivatization and inject LC-MS/(HRMS) methodology - Sakellariou - 2025 - Drug Testing and Analysis - Wiley Online Library
1 INTRODUCTION Anabolic agents are used by athletes to enhance their performance, despite their prohibition by WADA and their well-documented adverse health consequences.1, 2 19-norandrosterone (19-NA) is the major metabolite of the prohibited anabolic steroid nandrolone or its prohormones and is considered in its glucuronidated form as the target metabolite in sports drug testing to reveal nandrolone abuse.3 Based on the 2021 Anti-Doping Testing Figures, 62 Adverse Analytical Findings (AAFs)...
New long‐standing metabolites of 17α‐methyltestosterone are detected in HepG2 cell in vitro metabolic model and in human urine
1 INTRODUCTION Biotransformation studies are of paramount importance in the doping control field, as drug metabolites may substantially prolong the detection of the administrated substances prohibited by the World Anti-doping Agency (WADA). This is particularly important for some prohibited classes, like the anabolic androgenic steroids (AASs).
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