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1 Introduction Pancreatic Ductal Adenocarcinoma (PDAC), a highly invasive malignancy of the digestive system, predominantly occurs in individuals aged 65–75 years (1). Global population aging continues to drive its rising incidence, with the International Agency for Research on Cancer (IARC) reporting 510,600 new cases worldwide in 2022- underscoring a mounting disease burden (2).
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