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Articles by Pascal Bittel
The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools
Abstract Close-proximity interactions are considered a key risk factor for respiratory virus transmission, but their importance relative to shared space and air quality remains unclear. We conducted a six-week longitudinal study in a Swiss secondary school (67 students, aged 14–15). We detected 87 infections in saliva samples and recorded absences to identify plausible transmissions, excluding implausible ones through genomic analysis.
Absences, Symptoms and Respiratory Viruses in a Swiss School: Longitudinal Study With Serial Saliva Sampling
1 Introduction Respiratory infections remain a global public health concern, particularly among children and adolescents [1], where they account for a significant proportion of pediatric hospital admissions [2]. Respiratory viral infections spread mainly during the winter months in waves caused by different pathogens occurring simultaneously or consecutively, leading to an annual burden on outpatient and inpatient healthcare [3].
Optimized high-throughput whole-genome sequencing workflow for surveillance of influenza A virus - Genome Medicine
References Chauhan RP, Gordon ML. An overview of influenza A virus genes, protein functions, and replication cycle highlighting important updates. Virus Genes. 2022;58:255–69. https://doi.org/10.1007/S11262-022-01904-W. Article CAS PubMed Google Scholar Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG. Influenza. Nat Rev Dis Primers. 2018;4: 1–21. https://doi.org/10.1038/s41572-018-0002-y.
NASCarD (Nanopore Adaptive Sampling with Carrier DNA): A Rapid, PCR-Free Method for SARS-CoV-2 Whole-Genome Sequencing in Clinical Samples
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SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data
Loading metrics Open Access Peer-reviewed Research Article Citation: Banholzer N, Zürcher K, Jent P, Bittel P, Furrer L, Egger M, et al. (2023) SARS-CoV-2 transmission with and without mask wearing or air cleaners in schools in Switzerland: A modeling study of epidemiological, environmental, and molecular data. PLoS Med 20(5): e1004226.
Diagnostic accuracy of SARS-CoV-2 saliva antigen testing in a real-life clinical setting
Highlights • SARS-CoV-2 saliva antigen tests facilitate testing with poorly trained personnel • Their diagnostic accuracy in clinical settings is essentially unclear • We conducted a diagnostic accuracy study in a real-life clinical setting • The diagnostic accuracy of the PCL saliva antigen test was 30,2% • Application of the test might lead to a large number of false-negative test results Abstract Background: SARS-CoV-2 antigen tests with saliva facilitate examination in settings that lack...
Diagnostic accuracy of a SARS-CoV-2 rapid antigen test in real-life clinical settings
Highlights • High hopes are placed on SARS-CoV-2 rapid antigen tests • Their diagnostic accuracy in clinical settings is essentially unclear • A large diagnostic accuracy study was conducted in a real-life clinical setting • The diagnostic accuracy of the Roche/SD Biosensor test was 65% • Their application might lead to a considerable number of false-negative test results Abstract Background Laboratory tests are a mainstay in managing the COVID-19 pandemic, and high hopes are placed on rapid...
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