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Methods and analysis Design and setting The AddaMAP study is a multicentre prospective open label single-arm Simon’s two stage phase II trial which will investigate the impact of adding daptomycin (10 mg/kg/day for 8 days) to the recommended treatment (corticosteroids+third-generation cephalosporin) on disability-free survival (DFS) in adult patients with confirmed pneumococcal meningitis.
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