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Articles by Pascal Steullet
Myo-inositol concentration in the medial prefrontal cortex is associated with changes in brain white matter microstructure in early psychosis
Abstract Recent research highlights the critical role of white matter (WM) alterations in psychosis and schizophrenia (SZ), reporting volumetric and structural brain changes in affected individuals. In this study, we explored the role of astroglia in SZ, which is believed to play a role in white matter integrity.
Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization - Nature Communications
Abstract Network science has mapped brain structural and functional organization, yet capturing metabolic contrast remains a major gap in connectomics. Using fast, high-resolution 3D whole-brain proton magnetic resonance spectroscopic imaging (1H-MRSI), we derive a within-subject metabolic connectome in 51 healthy subjects, defined as pairwise correlations among five metabolites (tCr, tNAA, Glx, Ins, Cho) across gray-matter parcels.
Editorial for the Special Issue “Oxidative Stress, Inflammation and Antioxidant Defense System in Psychiatric Disorders” in Antioxidants (2022-2023)
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Associations Between Blood Markers of the GSH Redox cycle and Brain White Matter Microstructure in Psychosis
The authors have declared no competing interest. This work was supported by the Swiss National Science Foundation (PCEFP2_194260, to I.J.; 320030_197787 to PH and YA), the National Center of Competence in Research (NCCR) "SYNAPSY - The Synaptic Bases of Mental Diseases" from the Swiss National Science Foundation (51NF40_185897 to KQD & PC) and the Foundation Alamaya. Dr. Alameda is supported by Carigest fellowship and by Frutiger Adrian et Simone fellowship. Dr. Dwir and P.
White Matter Microstructure Alterations and Their Link to Symptomatology in Early Psychosis and Schizophrenia
The authors have declared no competing interest. This work was supported by the Swiss National Science Foundation (PCEFP2-194260, to I.J.), the National Center of Competence in Research (NCCR) SYNAPSY - The Synaptic Bases of Mental Diseases from the Swiss National Science Foundation (n 51NF40 - 185897 to KQD & PC) and the Foundation Alamaya. Dr Alameda is supported by Carigest fellowship and by Frutiger Adrian et Simone fellowship.
Sex-specific interactions between stress axis and redox balance are associated with internalizing symptoms and brain white matter microstructure in adolescents | Translational Psychiatry
Abstract Adolescence is marked by the maturation of systems involved in emotional regulation and by an increased risk for internalizing disorders (anxiety/depression), especially in females. Hypothalamic-pituitary-adrenal (HPA)-axis function and redox homeostasis (balance between reactive oxygen species and antioxidants) have both been associated with internalizing disorders and may represent critical factors for the development of brain networks of emotional regulation.
Developmental changes in cerebral NAD and neuroenergetics of an antioxidant compromised mouse model of schizophrenia - Translational Psychiatry
Abstract Defects in essential metabolic regulation for energy supply, increased oxidative stress promoting excitatory/inhibitory imbalance and phospholipid membrane dysfunction have been implicated in the pathophysiology of schizophrenia (SZ). The knowledge about the developmental trajectory of these key pathophysiological components and their interplay is important to develop new preventive and treatment strategies. However, this assertion is so far limited.
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