REVIEW article Volume 12 - 2025 | https://doi.org/10.3389/fvets.2025.1596316 This article is part of the Research TopicReviews in Pathology of Infectious Diseases - Volume IIView all 8 articles 1 Introduction Proliferative enteropathy (PE), also known as ileitis, is an infectious disease affecting pigs and other animals (like horses, rodents, rabbits and deer). It is caused by Lawsonia intracellularis, an obligately intracellular Gram-negative, microaerophilic, vibrioid-shaped bacterium.