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Articles by Patrick Ming-Kuen
Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression
1. Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong 2. Research Center for Integrated Chinese and Western Medicine, and Department of Cardiology, The Second Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China 3. Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong 4.
C-Reactive Protein Induces Immunosuppression by Activating FcγR2B in Pulmonary Macrophages to Promote Lung Metastasis
C-reactive protein (CRP) is a liver-derived acute phase reactant that is a clinical marker of inflammation associated with poor cancer prognosis. Elevated CRP levels are observed in many types of cancer and are associated with significantly increased risk of metastasis, suggesting that CRP could have pro-metastatic actions. Here, we reported that CRP promotes lung metastasis by dampening the anti-cancer capacity of pulmonary macrophages in breast cancer and melanoma.
Advance in Targeted Cancer Therapy and Mechanisms of Resistance
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Tumour-associated macrophages: versatile players in the tumour microenvironment
Introduction Tumour microenvironment (TME) is crucial for cancer initiation, progression, and drug resistance. TME is formed by various fundamental constituents including stromal cells and immune cells (Cassetta et al., 2019; Li et al., 2023; Wang et al., 2023). Cancer development can be facilitated by tissue inflammation (Nost et al., 2021; Rajamaki et al., 2021).
New Insights into Fibrotic Signaling in Renal Cell Carcinoma
Jiao-Yi CHEN1, Wai-Han YIU1, Patrick Ming-Kuen TANG2 and Sydney C.W. TANG1* 1Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong, SAR China 2Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, SAR China Provisionally accepted: The final, formatted version of the article will be published soon.
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