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1 Introduction Polyethylene 2,5-furanoate (PEF) represents an alternative to the omnipresent plastic polyethylene terephthalate (PET). Both PEF and PET maintain similar physical and thermoplastic characteristics, such as high gas barrier properties which make them particularly suited for food and beverage packing applications (Loos et al. 2020; De Jong et al. 2022).
Abstract Dosage-sensitive genes have characteristic patterns of evolution that include being refractory to small-scale duplication, depleted on human benign copy number variants (CNVs) and enriched on pathogenic CNVs. This intolerance to copy number change is likely due to an expression constraint that exists in one or more tissues.
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