Research Articles, Systems/Circuits Lingzhen Song, Xiaxia Xu, Peggy Putthoff, David Fleck, Marc Spehr and Ileana L. Hanganu-Opatz Journal of Neuroscience 26 January 2022, 42 (4) 601-618; DOI: https://doi.org/10.1523/JNEUROSCI.1203-21.2021 Abstract Precise information flow from the hippocampus (HP) to prefrontal cortex (PFC) emerges during early development and accounts for cognitive processing throughout life. On flip side, this flow is selectively impaired in mental illness.