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1 Introduction Cerebral small vessel disease (CSVD) represents a complex group of pathological processes primarily affecting the small arteries, arterioles, capillaries, and small veins in the brain. The disease was previously characterized by neuroimaging features including recent small subcortical infarcts, lacunes, white matter hyperintensities (WMH), enlarged perivascular spaces, cerebral microbleeds, and brain atrophy (Wardlaw et al.
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