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Peng Bu

As seen in: Nature, Wiley Online Library
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Articles by Peng Bu

KCNJ15 inhibits epithelial‑mesenchymal transition in colorectal cancer cell lines involving the PI3K/AKT/mTOR signaling pathway

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By Hongling Zhang, Jianghong Guo, Shuzhe Yang, Jie Wang, Yajing Wang, Wei Cui, Peng Bu, Ning Gao, Wenjun Xue, Fangfang Liu, Yanfeng Xi, Zhongyuan Bai, Guohai Zhao
| Nature Verified
Abstract KCNJ15 encodes the inwardly rectifying potassium channel Kir4.2, which is essential for maintaining cellular homeostasis and is implicated in tumor initiation and progression. In this study, we explored the expression profile, biological functions and molecular mechanisms of KCNJ15 in colorectal cancer (CRC) cells. Immunohistochemical analysis revealed that KCNJ15 was downregulated in CRC tissues, and its low expression was correlated with poor patient prognosis.
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Cancer cell‐derived exosomal miR‐20a‐5p inhibits CD8+ T‐cell function and confers anti‐programmed cell death 1 therapy resistance in triple‐negative breast cancer

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By Weina Li, Feng LI, Guohui Han, Peng Bu
| Wiley Online Library Verified
3'-UTR 3'-untranslated region cirmiRNAs circulating miRNAs EVs extracellular vesicles HNSCC head and neck squamous cell carcinoma miRNA microRNA NPAT nuclear protein ataxia-telangiectasia PD-1 programmed cell death 1 RLU luminescence units TNBC triple-negative breast cancer 1 INTRODUCTION As the leading cause of cancer-related death among women, breast cancer is classified into three subtypes based on the expression levels of estrogen, progesterone receptor and HER2 overexpression.1, 2...
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