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Articles by Per E. Andrén
Correction: Anabolic androgenic steroids induce distinct monoaminergic and lipidomic alterations in the male rat brain
Correction to: Neuropsychopharmacology https://doi.org/10.1038/s41386-026-02508-w, published online 26 August 2026 The first line in the second paragraph of Introduction is now revised to: When used recreationally, AAS are typically taken in 8–12-week cycles, often two to three times per year, at supraphysiological doses equivalent to approximately 250–5000 mg/week—approximately 5–100 times greater than the natural male production of testosterone [8].
Anabolic androgenic steroids induce distinct monoaminergic and lipidomic alterations in the male rat brain
Abstract The illicit use of anabolic androgenic steroids (AAS) to enhance physical strength, performance, and appearance is associated with severe physical and psychological adverse effects. Long-term AAS use has been associated with altered behavior and cognitive impairments. Nevertheless, the neurobiological effects of AAS use remain underexplored, especially in terms of brain neurotransmitter and lipid profiles.
Technology Matters: Integrating digital treatments for children and young people with anxiety disorders into routine care
What is currently known? Although digital cognitive behavioural therapy (CBT) can increase access to evidence-based care for children and young people with anxiety disorders, guidance is limited on how it should be integrated and sequenced within broader care models What has been shown?
Spatial lipidomic and neuron-specific transcriptomic signatures in the nucleus accumbens reveal phospholipid dyshomeostasis in depression-related maladaptations
Abstract Lipid systems play a substantial role in the pathophysiological mechanisms underlying several brain disorders. However, the mechanisms underlying the lipid profile in stress-induced maladaptations and how these changes can impact distinct neuronal circuits and behavioral states remain to be fully elucidated.
Intolerance of Uncertainty, Cognitive Avoidance, Positive Beliefs About Worry and Negative Problem Orientation: Relevance to Anxiety Disorders, OCD and Depression in Youth
1 Introduction Psychiatric disorders are the leading cause of disability in children and adolescents (hereinafter, youth; ~7–17 years), with internalizing disorders (e.g., anxiety, obsessive-compulsive and depressive disorders) being most common (Kieling et al. 2024). The first-line treatment for these disorders is cognitive-behavioural therapy (CBT).
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling - Communications Biology
Abstract Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the roles of these peptides in pancreatic endocrine function, morphology, neurotransmitter dynamics, and systemic glucose homeostasis.
Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior - Molecular Psychiatry
Abstract Ketamine may be a novel pharmacologic approach to enhance resilience and protect against stress-related disorders, but the molecular targets underlying this response remain to be fully characterized. The multifunctional protein p11 is crucial in the pathophysiology of depression and antidepressant responses. However, it is still unclear whether p11 plays a role in the pro-resilience effects induced by ketamine.
Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome
Key Points Question Is therapist-supported, internet-delivered exposure and response prevention (ERP) for youths with Tourette syndrome or chronic tic disorder efficacious and cost-effective in the long term, compared with therapist-supported, internet-delivered psychoeducation?
Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents - Nature Communications
Abstract Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson’s disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-mortem brain of PD patients. Altered plasma and CSF PSAP levels correlate with PD-related motor impairments.
Spatial multimodal analysis of transcriptomes and metabolomes in tissues - Nature Biotechnology
Abstract We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson’s disease.
Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling
8 Matrix Thermal Shift Assay for Fast Construction of Multidimensional Ligand-Target Space Ruan, Chengfei; Wang, Yan; Zhang, Xiaolei; Lyu, Jiawen; Zhang, Na; Ma, Yanni; Shi, Chunzhen; Qu, Guangbo; Ye, Mingliang Analytical Chemistry (Washington, DC, United States) (2022), 94 (17), 6482-6490CODEN: ANCHAM; ISSN:0003-2700. (American Chemical Society) Existing thermal shift-based mass spectrometry approaches are able to identify target proteins without chem.
Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents With Tourette Syndrome: A Randomized Clinical Trial | Adolescent Medicine | JAMA Network Open | JAMA Network
Therapist-Supported Internet-Delivered Exposure and Response Prevention for Children and Adolescents With Tourette Syndrome: A Randomized Clinical Trial | Adolescent Medicine | JAMA Network Open | JAMA Network [Skip to Navigation] Figure 2.
Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging
Abstract We present a mass spectrometry imaging (MSI) approach for the comprehensive mapping of neurotransmitter networks in specific brain regions. Our fluoromethylpyridinium-based reactive matrices facilitate the covalent charge-tagging of molecules containing phenolic hydroxyl and/or primary or secondary amine groups, including dopaminergic and serotonergic neurotransmitters and their associated metabolites.
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