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Articles by Per Selnes
Segmenting white matter hyperintensities on isotropic three-dimensional Fluid Attenuated Inversion Recovery magnetic resonance images: Assessing deep learning tools on a Norwegian imaging database (pdf) | Paperity
PLOS ONE, Aug 2023 An important step in the analysis of magnetic resonance imaging (MRI) data for neuroimaging is the automated segmentation of white matter hyperintensities (WMHs). Fluid Attenuated Inversion Recovery (FLAIR-weighted) is an MRI contrast that is particularly useful to visualize and quantify WMHs, a hallmark of cerebral small vessel disease and Alzheimer’s disease (AD).
Diffusion tensor and restriction spectrum imaging reflect different aspects of neurodegeneration in Parkinson’s disease
Loading metrics Open Access Peer-reviewed Research Article Tuva R. Hope , Per Selnes, Irena Rektorová , Lubomira Anderkova , Nela Nemcova-Elfmarkova , Zuzana Balážová , Anders Dale, Atle Bjørnerud, Tormod Fladby Tuva R.
Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease
To our knowledge, this is the first study showing that Ng/BACE1 level is increased already at a preclinical stage of AD. Ng/BACE1 levels were equally increased in both Aβ+ MCI and SCD groups compared with controls, and no difference in Ng/BACE1 levels between APOE-ɛ4 +/− controls were found. Increased Ng/BACE1 level was the only marker related to baseline hippocampal and amygdala volumes in our sample.
«Lyse utsikter for behandling mot demens»
Denne innsikten har vært ledende for utvikling av diagnostikk og behandling mot demens de siste årene. Det er særlig for Alzheimers sykdom, den vanligste årsaken til demens, at man i dag har store forhåpninger til ny forskning på behandling, slik vi driver med. Tradisjonelle diagnosekriterier for Alzheimers sykdom forutsetter at demenssykdommen allerede er etablert. Dette gjør at vi mister muligheten til å behandle tidlig i perioden der man er syk, men ennå ikke har betydelige symptomer.
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