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2.3. Optimization of Baicalin Glucoside Synthesis and Yield through Design of Experiment The optimization of baicalin glucosides synthesis was achieved through an experiment and analysis via the response surface methodology. The variables (baicalin concentration, α-cyclodextrin concentration, temperature, enzyme content, and pH) and the data of the Central-Composite-Face-Centered (CCF) design applied are presented in Table 2.
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