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Articles by Peter A. A
Trogocytosis drives red blood cell antigen loss in association with antibody-mediated immune suppression
Red blood cell (RBC) alloimmunization to paternal antigens during pregnancy can cause hemolytic disease of the fetus and newborn (HDFN). This severe and potentially fatal neonatal disorder can be prevented by the administration of polyclonal anti-D through a mechanism referred to as antibody-mediated immune suppression (AMIS). Although anti-D prophylaxis effectively prevents HDFN, a lack of mechanistic clarity has hampered its replacement with recombinant agents.
Serum from half of patients with immune thrombocytopenia trigger macrophage phagocytosis of platelets
We observed that serum from about half (42%) of the MHC I alloantibody-negative patients with ITP in our cohort triggered macrophage phagocytosis of normal donor platelets. The ability of a particular ITP serum to trigger phagocytosis was associated with the presence of detectable autoantibodies: 8 of 14 autoantibody-positive sera and 0 of 5 autoantibody-negative sera triggered phagocytosis of platelets.
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcγ receptor inhibition
Skip Nav Destination TRANSFUSION MEDICINE| April 15, 2021 You do not currently have access to this content. Sign in via your Institution
Inhibition of platelet phagocytosis as an in vitro predictor for therapeutic potential of RBC antibodies in murine ITP
TRANSFUSION MEDICINE| June 25, 2020 You do not currently have access to this content.
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