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Articles by Peter Manza
Longitudinal Precision Functional Mapping in Psychiatry
Functional network connectivity is a fundamental element of large-scale brain organization, well suited to linking psychiatric symptoms with underlying neural substrates and identifying novel biomarkers. Capturing trait-like differences between individuals and state-dependent fluctuations within individuals, network connectivity has clear mechanistic links to the expression of psychiatric illness.
Neuroanatomical subtypes of preterm adolescents
Abstract Preterm infants have a higher risk for developing neurocognitive deficits and behavioral abnormalities across the lifespan, but the individual long-term neurobiological heterogeneity presents a challenge for developmental risk assessment and outcome prediction.
Bifunctional modulation of NMDA and opioid receptors in ketamine reinforcement and misuse: implications for substance use disorder treatment
Get full text access Log in, subscribe or purchase for full access. References 1. Wilkinson, S.T. ∙ Palamar, J.J. ∙ Sanacora, G. The Rapidly Shifting Ketamine Landscape in the US JAMA psychiatry. 2024; 81:221-222 2. Wilkinson, S.T. ∙ Toprak, M. ∙ Turner, M.S. ... A Survey of the Clinical, Off-Label Use of Ketamine as a Treatment for Psychiatric Disorders The American journal of psychiatry. 2017; 174:695-696 3. Gao, M. ∙ Rejaei, D. ∙ Liu, H. Ketamine use in current clinical practice Acta Pharmacol Sin.
Methylphenidate Promotes a Frontoparietal-Dominant Brain State Improving Cognitive Performance: A Randomized Trial
brain dynamics fMRI PET visuospatial Significance Statement Methylphenidate (MP) is primarily prescribed for attention-deficit/hyperactivity disorder, but it is also misused as a cognitive enhancer by individuals seeking to improve cognitive performance. Using advanced brain imaging and behavioral tasks, this study investigates how MP affects dopamine signaling, brain activity, and cognitive performance.
Stimulant medications in children with ADHD normalize the structure of brain regions associated with attention and reward - Neuropsychopharmacology
Abstract Children with ADHD show abnormal brain function and structure. Neuroimaging studies found that stimulant medications may improve brain structural abnormalities in children with ADHD. However, prior studies on this topic were conducted with relatively small sample sizes and wide age ranges and showed inconsistent results.
Brain connectivity changes to fast versus slow dopamine increases - Neuropsychopharmacology
Volkow ND, Wise RA, Baler R. The dopamine motive system: implications for drug and food addiction. Nat Rev Neurosci. 2017;18:741–52. Article CAS PubMed Google Scholar Allain F, Minogianis EA, Roberts DCS, Samaha AN. How fast and how often: the pharmacokinetics of drug use are decisive in addiction. Neurosci Biobehav Rev. 2015;56:166–79. Article PubMed Google Scholar Ferrario CR, Shou M, Samaha AN, Watson CJ, Kennedy RT, Robinson TE.
Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders
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Neural circuit selective for fast but not slow dopamine increases in drug reward - Nature Communications
Abstract The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits underlying the rate dependency to drug reward remain unresolved. With simultaneous PET-fMRI we linked dynamics of dopamine signaling, brain activity/connectivity, and self-reported ‘high’ in 20 adults receiving methylphenidate orally (results in slow delivery) and intravenously (results in fast delivery) (trial NCT03326245).
Disrupted brain state dynamics in opioid and alcohol use disorder: attenuation by nicotine use - Neuropsychopharmacology
Abstract Substance use disorder (SUD) is a chronic relapsing disorder with long-lasting changes in brain intrinsic networks. While most research to date has focused on static functional connectivity, less is known about the effect of chronic drug use on dynamics of brain networks.
Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review
1. Introduction The implementation of combined antiretroviral therapy (cART) in the global healthcare system has improved health-related quality of life for people living with HIV (PLWH). Historically, HIV was considered a terminal condition and has been recharacterized as a manageable chronic condition based on cART’s ability to reduce comorbidities and prolong survival [1,2].
Ketogenic diet reduces a neurobiological craving signature in alcohol use disorder
The authors have declared no competing interest. NCT03255031 This work was accomplished with support from the National Institute on Alcohol Abuse and Alcoholism, Intramural Research Program (Y1AA-3009 to Dr. Volkow). Dr. Wiers was supported by a NARSAD Young Investigator Grant (28778), and a K99/R00 grant AA026892. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Hippocampal volume loss in individuals with a history of non‐fatal opioid overdose
1 INTRODUCTION Opioid use disorder (OUD) is a chronic, relapsing disease with high mortality and morbidity. OUD disproportionally affects younger adults, with opioid-related fatalities accounting for up to 20% of deaths among individuals 24–35 years of age.
Habenula volume and functional connectivity changes following laparoscopic sleeve gastrectomy for obesity treatment
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Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions - Molecular Psychiatry
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans - Communications Biology
Abstract Dopamine facilitates cognition and is implicated in reward processing. Methylphenidate, a dopamine transporter blocker widely used to treat attention-deficit/hyperactivity disorder, can have rewarding and addictive effects if injected. Since methylphenidate’s brain uptake is much faster after intravenous than oral intake, we hypothesize that the speed of dopamine increases in the striatum in addition to its amplitude underly drug reward.
Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9‐ to 11‐year‐old children
Rui Zhang, 1 Peter Manza, 1 and Nora D. Volkow 1 , 2 Rui Zhang 1 Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda MD, USA Peter Manza 1 Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda MD, USA Nora D.
Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9‐ to 11‐year‐old children
Abstract Background Despite the widespread use of caffeine including consumption during pregnancy, the effect of prenatal caffeine exposure on child brain development and behavior is unclear. Methods To address this, we used data from the Adolescent Brain and Cognitive Development Study (n = 11,875 children aged 9–11 years from 22 sites across the United States).
Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
Abstract Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects.
Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
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Akinetic rigid symptoms are associated with decline in a cortical motor network in Parkinson’s disease
Abstract The akinetic/rigid (AR) motor subtype of Parkinson’s Disease is associated with increased rates of motor and cognitive decline. Cross-sectional studies examining the neural correlates of AR have found abnormalities in both subcortical and cortical networks involved in motor planning and execution relative to controls.
Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects
The primary results from the meta-analysis demonstrated that individuals with PD show deficits in response inhibition performance, specifically on tasks that test cognitive control of behavioral responses, including SST, Go-NoGo, Anti-saccade, and Stroop tasks.
The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop-signal task
To adapt flexibly to a rapidly changing environment, humans must anticipate conflict and respond to surprising, unexpected events. To this end, the brain estimates upcoming conflict on the basis of prior experience and computes unsigned prediction error (UPE). Although much work implicates catecholamines in cognitive control, little is known about how pharmacological manipulation of catecholamines affects the neural processes underlying conflict anticipation and UPE computation.
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