Skip to Content Trusted evidence. Informed decisions. Better health. Access provided by: Swiss Academy of Medical Sciences (SAMS) and partners PICOs The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.