1 INTRODUCTION Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare and deadly hyperinflammatory syndrome with a reported 90-days mortality of up to 81% in critically ill patients.1, 2 Diagnosis is established by the HLH-2004 criteria, the current clinical standard harboring eight criteria, of which at least five need to be fulfilled for HLH diagnosis.3, 4 These criteria were primarily developed for pediatric patients and are recommended for diagnosis in adults despite missing...
