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Articles by Peter Parham
Mouse lemur cell atlas informs primate genes, physiology and disease - Nature
Abstract Mouse lemurs (Microcebus spp.) are an emerging primate model organism, but their genetics, cellular and molecular biology remain largely unexplored. In an accompanying paper1, we performed large-scale single-cell RNA sequencing of 27 organs from mouse lemurs. We identified more than 750 molecular cell types, characterized their transcriptomic profiles and provided insight into primate evolution of cell types.
KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behçet Disease
Open Access Harry Petrushkin, Paul J. Norman, Emma Lougee, Peter Parham, Graham R. Wallace, Miles R. Stanford and Farida Fortune J Immunol September 15, 2019, 203 (6) 1629-1635; DOI: https://doi.org/10.4049/jimmunol.1801178 Key Points KIR3DL1 allotypes impact the development of Behçet disease. This association appears to be independent of the effect of HLA-B*51. Different KIR3DL1 allotypes are associated with mucocutaneous and ophthalmic disease.
KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behçet Disease
Open Access Harry Petrushkin, Paul J. Norman, Emma Lougee, Peter Parham, Graham R. Wallace, Miles R. Stanford and Farida Fortune J Immunol August 12, 2019, ji1801178; DOI: https://doi.org/10.4049/jimmunol.1801178 Key Points KIR3DL1 allotypes impact the development of Behçet disease. This association appears to be independent of the effect of HLA-B*51. Different KIR3DL1 allotypes are associated with mucocutaneous and ophthalmic disease.
Variable NK Cell Receptors Exemplified by Human KIR3DL1/S1
Abstract Variegated expression of variable NK cell receptors for polymorphic MHC class I broadens the range of an individual’s NK cell response and the capacity for populations and species to survive disease epidemics and population bottlenecks. On evolutionary time scales, this component of immunity is exceptionally dynamic, unstable, and short-lived, being dependent on coevolution of ligands and receptors subject to varying, competing selection pressures.
Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation
Natural killer (NK) cells are lymphocytes of innate immunity that respond to virus infected and tumor cells. After allogeneic transplantation, NK cells are the first reconstituting lymphocytes, but are dysfunctional. Manipulating this first wave of lymphocytes could be instrumental in reducing the 40% relapse rate following transplantation with reduced-intensity conditioning. NK cells express numerous activating and inhibitory receptors.
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