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Articles by Peter Wright
Linker Length and Composition within Disordered Binding Motifs modulates the Avidity and Reversibility of a Multivalent Protein Interaction Switch
Abstract Intrinsically disordered proteins that mediate the cellular transcriptional response to hypoxia play important roles in turning on and turning off oxygen stress genes. In particular, the feedback inhibitor CITED2 operates a unidirectional switch that efficiently terminates the hypoxic response by displacing the C-terminal activation domain of the hypoxia-inducible factor HIF-1α from its complex with the TAZ1 domain of the transcriptional coactivators CBP and p300.
Changing food conditions and size declines in a North Sea forage fish
Abstract Declining body sizes are prevalent in marine fish. While these declines have been suggested to be a response to increasing temperatures, the evidence is mixed and the underlying causes of observed declines often unknown. Here, we explore drivers of spatio-temporal patterns in size in lesser sandeel (Ammodytes marinus), an important prey for seabirds and marine mammals, focusing on ongoing size declines in the North Sea.
Switchable client specificity in a dual functional chaperone coordinates light harvesting complex biogenesis
Abstract The proper assembly of light harvesting complexes (LHCs) is critical for photosynthesis and requires the biogenesis of light-harvesting chlorophyll a,b-binding proteins (LHCPs) to be coordinated with the biosynthesis of chlorophylls (Chl). The mechanism underlying this coordination is not well understood. Here we show that a conserved molecular chaperone in chloroplasts, cpSRP43, provides a molecular thermostat that helps maintain this coordination.
"Preface" by Peter Wright
Keywords Historians, historical research, self-discovery Abstract The eminent Russian humanist and novelist Leo Tolstoy once quipped, "Historians are like deaf people who go on answering questions that no one has asked them." Although Tolstoy intended this to be a criticism of contemporary historical trends, his thought reveals an important truth about the value of historical studies: historians often investigate questions that others never think to explore and thus provide new and unique...
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