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1 Introduction Monocytes and macrophages play an important role in the innate immune defense against a variety of pathogens (1). The pro-inflammatory cytokine interleukin (IL)-1β importantly contributes to the acute phase response, a systemic reaction to infections, autoimmune reactions, and tissue damage (2–4). Due to this potent, ubiquitous function, the synthesis and release of IL-1β must be strictly regulated and usually depends on two “danger signals”.
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