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Philipp Solbach

As seen in: Nature
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Articles by Philipp Solbach

Colonic spatial single-cell proteomics and murine models link mitochondrial dysfunction to dimeric IgA-secreting plasma cell deficiency in Crohn’s disease | Nature Communications

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By Philipp Solbach, Martha M. Kirstein, Jens Marquardt, Franziska Schmelter, Ulrich L. Günther, Miriam Wiestler, Hauke C. Tews, Dominik Bettenworth, Matthias Peipp, Thomas Valerius, Mohab Ragab, Thorben Sauer, Marc Ehlers, Philip Rosenstiel, Rudolf A. Manz, Axel Künstner, Hauke Busch, Christian Sina, Stefanie Derer, Annika Raschdorf, Heidi Schlichting, Maren Hicken, Lea Christiansen, Timo Gemoll
| Nature Verified
Abstract Secretory IgA (SIgA) is critical for maintaining the intestinal barrier. A dysregulated B-cell compartment and altered Ig secretion have been well documented in Crohn’s disease (CD) patients, although their origin is unknown.
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BaiCD gene cluster abundance is negatively correlated with Clostridium difficile infection

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By Patrick Chhatwal, Evelina Tacconelli, Philipp Solbach, Sabrina Woltemate
| PLOS
The prevalence of the baiCD gene cluster was significantly higher in C. difficile negative fecal samples than in samples of patients diagnosed with CDI (72.5% (100/138) vs. 35.9% (23/64; p<0.0001). No differences in baiCD gene cluster prevalence were seen between NC and NTCD or NC and TCD samples. Both rCDI patients were baiCD-negative at baseline, but one of the two patients turned positive after successful FMT from a baiCD-positive donor.
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