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Phillip J. Bergenb on Muck Rack

Phillip J. Bergenb

As seen in: American Society for Microbiology (ASM)
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Articles by Phillip J. Bergenb

Optimization and Evaluation of Piperacillin-Tobramycin Combination Dosage Regimens against Pseudomonas aeruginosa for Patients with Altered Pharmacokinetics via the Hollow-Fiber Infection Model and Mechanism-Based Modeling

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By Phillip J. Bergenb, Roger L. Nationa, Steven C. Wallisd, David L. Patersond
| American Society for Microbiology (ASM)
Augmented renal clearance (ARC) in critically ill patients can result in suboptimal drug exposures and treatment failure. Combination dosage regimens accounting for ARC have never been optimized and evaluated against Pseudomonas aeruginosa by use of the hollow-fiber infection model (HFIM). Using a P.
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Optimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model

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By Vanessa E. Reesa, Phillip J. Bergenb, John D. Boyced, Anton Y. Pelegd
| American Society for Microbiology (ASM)
Hypermutable Pseudomonas aeruginosa strains are prevalent in patients with cystic fibrosis and rapidly become resistant to antibiotic monotherapies. Combination dosage regimens have not been optimized against such strains using mechanism-based modeling (MBM) and the hollow-fiber infection model (HFIM).
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