If ARDS persists for more than 5 days after diagnosis it is considered as ‘non-resolving’ and the risk of fibrosis formation is considerable if the cause for ARDS remains untreated [3, 30]. There are several studies that show that reactivation of HSV and CMV is frequent in non-resolving ARDS [31,32,33]. No randomized trials have been conducted on whether or not to treat HSV reactivations, but observational studies suggest independent excess mortality in the HSV and CMV group.
