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Articles by Pieter Simons

Inhaled Δ9-tetrahydrocannabinol does not enhance oxycodone-induced respiratory depression: randomised controlled trial in healthy volunteers

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By Monique van Velzen, Maarten van Lemmen, Pieter Simons, Kiki W.K. Kuijpers
| bjanaesthesia.org
Abstract Background In humans, the effect of cannabis on ventilatory control is poorly studied, and consequently, the effect of Δ9-tetrahydrocannabinol (THC) remains unknown, particularly when THC is combined with an opioid. We studied the effect of THC on breathing without and with oxycodone pretreatment. We hypothesised that THC causes respiratory depression, which is amplified when THC and oxycodone are combined.
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Buprenorphine: a treatment and cause of opioid-induced respiratory depression

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By Albert Dahan, Simone Jansen, Maarten van Lemmen, Pieter Simons
| bjanaesthesia.org
Over the last decade, physicians and the public have become aware of the opioid epidemic with thousands of deaths each year, which is today considered the second major medical disaster after the COVID-19 pandemic in the USA. In 2020, around 92 000 citizens died from an opioid overdose in the USA alone. 2 Mattson C.L. Tanz L.J. Quinn K. Kariisa M. Patel N.L. Trends and geographic patterns in drug and synthetic opioid overdose deaths—United States, 2013–2019. MMWR Morb Mortal Wkly Rep.
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