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Articles by Pingting Wang
Oxajulolidinyl-Induced Molecular Twisting in Aza-BODIPY Nanoplatform for NIR-Triggered Synergistic Phototherapy of Glioblastoma
1 Introduction Glioblastoma remains a major threat to human longevity, and its clinical management is largely confined to the standard tri-modality regimens of surgical resection, radiotherapy, and temozolomide chemotherapy [1-3]. However, the fundamental limitation lies in the inherent inability of macroscopic tumor resection to address diffusely infiltrating tumor cells, a shortcoming that inexorably precipitates local recurrence [4, 5].
Aligned electrospun porous P34HB/lecithin scaffold for bone tissue regeneration
Abstract Bone tissue engineering has emerged as a promising restorative strategy for bone regeneration, yet it remains challenging to develop an appropriate scaffold with optimal porous microstructure for bone repair. Unlike random fibrous scaffolds, the aligned nanofibrous structure could provide contact guidance for cell orientation and enhances mechanotransduction signaling.
Monocyte-derived macrophage recruitment mediated by TRPV1 is required for eardrum wound healing
Abstract The tympanic membrane (TM), or eardrum, is a thin, sensitive tissue critical for hearing by vibrating and transmitting sound waves to the inner ear. TM perforation and development of otitis media and conductive hearing loss are commonly seen in the clinic. In this study, we demonstrate the role of TRPV1 signaling mediated macrophage recruitment and angiogenesis in TM repair.
Mixed Wolbachia infections resolve rapidly during in vitro evolution
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Mirchandani C, Wang P, Jacobs J, Genetti M, Pepper-Tunick E, Sullivan WT, et al. (2024) Mixed Wolbachia infections resolve rapidly during in vitro evolution. PLoS Pathog 20(7): e1012149. https://doi.org/10.1371/journal.ppat.1012149 Editor: Elizabeth A.
A Structural Proteome Screen Identifies Protein Mimicry in Host-Microbe Systems
Abstract Host-microbe systems are evolutionary niches that produce coevolved biological interactions and are a key component of global health. However, these systems have historically been a difficult field of biological research due to their experimental intractability. Impactful advances in global health will be obtained by leveraging in silico screens to identify genes involved in mediating interspecific interactions.
Mixed Wolbachia infections resolve rapidly during in vitro evolution
Abstract The intracellular symbiont Wolbachia pipientis evolved after the divergence of arthropods and nematodes, but it reached high prevalence in many of these taxa through its abilities to infect new hosts and their germlines. Some strains exhibit long-term patterns of co-evolution with their hosts, while other strains are capable of switching hosts. This makes strain selection an important factor in symbiont-based biological control.
KDM6A promotes chondrogenic differentiation of periodontal ligament stem cells by demethylation of SOX9
KDM6A has been demonstrated critical in the regulation of cell fates. However, whether KDM6A is involved in cartilage formation remains unclear. In this study, we investigated the role of KDM6A in chondrogenic differentiation of PDLSCs, as well as the underlying epigenetic mechanisms. KDM6A shRNA was transfected into PDLSCs by lentivirus. The chondrogenic differentiation potential of PDLSCs was assessed by Alcian blue staining.
KDM6A promotes chondrogenic differentiation of periodontal ligament stem cells by demethylation of SOX9
KDM6A has been demonstrated critical in the regulation of cell fates. However, whether KDM6A is involved in cartilage formation remains unclear. In this study, we investigated the role of KDM6A in chondrogenic differentiation of PDLSCs, as well as the underlying epigenetic mechanisms. KDM6A shRNA was transfected into PDLSCs by lentivirus. The chondrogenic differentiation potential of PDLSCs was assessed by Alcian blue staining.
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